Treatment of seasonal affective disorder
- thomas97972
- Aug 26, 2023
- 5 min read
Updated: Mar 26
Where caffeinated beverages have not been drunk there may be no need for a treatment of seasonal affective disorder. Caffeine can dysregulate calcium homeostases. Getting off supplements listed below could be very difficulty even almost impossible.
100 mg caffeine pills marketed by Bulksupplements could be taken where supplements listed below are taken. Coffee, tea, sodas, energy drinks and other caffeinated beverages are not drunk due to containing dietary antioxidants as phenols or as polyphenols.
A treatment to increase acetylcholine and dopamine levels could also be required. See this post.
Seasonal affective disorder is due to dysregulations in calcium homeostasis. Supplements that enhance calcium homeostasis can treat seasonal affective disorder. Vitamin K2 MK-7 and vitamin D3 can assist can assist with calcium homeostasis.
Seasonal affective disorder is a disorder where there are difficulties where there are alterations in received sunlight. Seasonal affective disorder is more noticeable in winter months where there are more alterations from received sunlight to no received sunlight. In seasonal affective disorder moods become very bleak in seconds when clouds suddenly block the sun. Moods in seasonal affective disorder become less bleak where buildings are entered where alterations in received sunlight stop for some hours.
Where caffeinated beverages have not been drunk there may be no need for a treatment of seasonal affective disorder. Caffeine can dysregulate calcium homeostasis.
There are lots of links to particular supplements. I am not an Amazon Associate. There are however so many ways to go wrong with supplements that links are provided.
Caffeine can agonizes ryanodine receptors releasing calcium. Release of calcium by antagonizing ryanodine receptors can worsen seasonal affective disorder. Caffeine containing drinks should not be drunk.
100-400 micrograms of vitamin K2 MK-7 marketed by Bronson is supplemented 3 times a day on basically empty stomachs were calcium orotate and magnesium ororate are supplemented for enhanced calcium homeostases. Vitamin K2 MK-7 from Bronson is a dry formulation.
Vitamin K2 MK-7 in softgel formulations is not effective. Vitamin K2 MK-7 has to be available in gastrointestinal tracts and systematically. Softgels are very effective in increasing absorptions and as as strong rule of thumb are not taken.
Vitamin K2 MK-7 should not be from natto as vitamin K2 MK-7 from natto is a plant extract. Plant extracts should not ever by taken and I underline ever. See this post.
Vitamin K2 MK-7 has low toxicity. Vitamin K2 Mk-7 has to be taken in three divided dosages.
Vitamin K2 MK-7 has a half-life of approximately 3 days. Vitamin K MK-7 should be in a dry formulation. Working up to higher dosages of vitamin K2 MK-7 could take some time.
Calcium ions are bound by GLA domain proteins. GLA domain proteins require vitamin K to bind calcium.
A One-A-Day pill is supplemented daily. A One-A-Day pill in broken in half where a half of a pill is supplemented in mornings where dinners are eaten and a half a pill is supplemented in evenings where dinners are eaten.
Vitamin D3 beyond what is a One-A-Day is not supplemented. Vitamin D3 beyond what is a One-A-Day could upset balances between VDR receptors and RXR receptors.
Supplements with fat-soluble nutrients have to be refrigerated. Supplements with vitamin D3, vitamin A, and/or vitamin K2 MK-7 have to be refrigerated.
Around 3600 milligrams of calcium orotate is supplemented three times a day on basically empty stomachs for increased absorptions of orotate. Calcium orotate is around 11% calcium and 89% orotate for a calcium dosage around 400 milligrams. Orotate is used to synthesize uridine monophosphate through uridine monophosphate synthetase. See top left of diagram.
Around 3600 milligrams of calcium orotate has around 400 milligrams of calcium. Calcium orotate marketed by Bulksupplements is supplemented.
Around 1500 mg. of magnesium orotate is supplemented three times a day on basically empty stomachs for increased absorptions of orotate. Magnesium orotate is around 7% magnesium where 1500 mg of magnesium orate would deliver around a 100 mg dosage of magnesium. Magnesium orotate marketed by BulkSupplements is supplemented.
Orotate has benefits where megadosages of vitamin C have been taken and/or acidic drinks have been drunk. See this post. Also see this post.
Calcium levels have to be tested. Comprehensive metabolic panels which test calcium levels can be ordered online.
Magnesium levels have to be tested. Magnesium tests can also be ordered online.
Minerals bound to acids, for example, citrate, do not work. Ingested organic acids can also have lots of side-effects.
Aldehyde oxidase is a molybdenum containing protein. Aldehyde oxidase is required for metabolism of vitamin A to 9-cis retinoic acid.
There has been a huge amount of research on vitamin D. Vitamin D receptors form heterodimers with retinoid-X-receptors (RXRs).
9-cis retinoic acid in a strong ligand for RXR receptors. 9-cis retinoic acid is an endogenous ligand for RXR receptors. With low levels of 9-cis retinoic acid vitamin D receptors do not work
There are difficulties with vitamin D regulated processes where difficulties are in part due to low formation of 9-cis retinoic acid. Supplementation with molybdenum increases activities of molybdenum containing proteins. Effects of supplementation with molybdenum could be undermined by dietary antioxidants.
200 micrograms of molybdenum from molybdenum bisglycinate is supplemented three times a day where dinners are eaten. Molybdenum from molybdenum glycinate marketed by Kirkman is supplemented. Supplementing more than 200 micrograms of molybdenum from molybdenum bisglycinate three times a day is not better.
Aldehyde oxidase requires O2. Antioxidants for example green tea can strongly decrease activities of aldehyde oxidase 1.
Illnesses due to shortages of 9-cis retinoic acid could have aspects beyond rickets. Constitutive androstane receptors, farnesoid X receptors, liver X receptors, peroxisome proliferator-activated receptors, pregnane X receptor, retinoic acid receptors, thyroid hormone receptors as well as vitamin D receptors form hetereodimers with RXRs
Legumes are symbiotic with nitrogenase containing organisms. Nitrogenase is a molybdenum containing protein but oxidation states of molybdenum in nitrogenase are not oxidation states of human molybdenum-dependent proteins. Legumes, for example, beans and soy, contain high levels of molybdenum from nitrogenase. Peanuts are legumes too.
Molybdenum from legumes by not being in correct oxidation states for human molybdenum proteins could adversely affect human molybdenum-containing proteins. In treatment of seasonal affective disorders eating legumes, for example, beans. peanuts and/or soy have to be avoided. Soy is in lots of food items, for example condiments and salad dressings. Ingredients labels of foods have to be checked and foods with soy not eaten.
To treat illnesses connected to dysregulations of calcium homeostases dietary antioxidants have to be avoided. Foods with spices have to be avoided and antioxidant-laden drinks, particularly sodas and/or sports drinks have to be avoided. Foods with natural and/or artificial flavors have to be avoided. Supplements containing antioxidants should not be taken however an appropriately formulated multivitamin pill containing around RDA amounts of antioxidant vitamins can be supplemented a sole time a day.
Treatment of seasonal affective disorders is not a minor course correction. Seasonal affective disorders are major mental illnesses that can result in desolations.
Individuals treated for seasonal affective disorder could still have depressions, chronic fatigue syndrome/long haul COVID-19 and/or difficulties with dietary antioxidants. To treat depressions see this post. To treat chronic fatigue syndrome/long-haul COVID-19 see this post. To re-regulate systematic oxidant defenses and address high levels of antioxidants in diets see this post.